Dec. 2, 2020: The United Kingdom Becomes the First Western Nation to Authorize a COVID-19 Vaccine
On Dec. 2, 2020, the UK's medicines regulator, the MHRA, granted temporary authorization to the vaccine developed by Pfizer and BioNTech. It was the first time a Western country had approved a fully tested COVID-19 vaccine for public use, and it came barely eleven months after the virus first appeared in the news.
The Green Light
The decision followed a rolling review of data from the companies' large Phase 3 trial, which had reported roughly 95 percent efficacy against symptomatic COVID-19. The regulator's approval allowed the shot to be supplied under temporary authorization, and Prime Minister Boris Johnson announced the news on social media, calling it incredible. The vaccine was built on messenger RNA, a technology that had never before been used in an approved vaccine for the public. Researchers had spent years refining it in relative obscurity, and now it had gone from laboratory promise to government approval in a stretch of months that vaccine specialists once would have considered impossible. The approval also set off an unusual bit of international jostling. Other countries, whose regulators were still deep in their own reviews, now had to explain why a rival had reached the finish line first. For a pandemic that had made borders, schedules and ordinary life feel unmovable, the speed of the paperwork was, in its own way, a small shock.
The first people in Britain to be vaccinated would not have to wait long. On Dec. 8, Margaret Keenan, a 90-year-old woman in Coventry, became the first person in the world to receive the Pfizer-BioNTech shot outside a clinical trial, in a hospital that had been turned into one of the country's first vaccination hubs. The U.S. Food and Drug Administration followed with its own emergency use authorization on Dec. 11, and other nations soon joined in. The approval did not end the pandemic; cases and deaths kept climbing through the winter, and supplies were limited at first. But it changed the shape of the story. After months in which the most hopeful news was a downward curve on a chart, the headline now involved something people could actually roll up a sleeve for. The most anticipated science of the year arrived not with fanfare, but with a regulatory notice.
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